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All authors thoroughly reviewed and agreed upon the final manuscript

Incorporation of cerebral blood flow-regulatory compoundssuch as vinpocetineinto an ionizable lipid demonstrates outstanding potential, highlighting a brain-protective activity and safe administration in APP/PS1 mice ( 4.2.1.2 Nanostructured lipid carriers (NLCs) Nanostructured lipid carriers (NLCs) are second-generation lipid carriers that share similar physicochemical properties with SLNs

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