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This effect was associated with the assembly of ZO-2, occludin and claudin-1, as well as increased expression of claudin-4 and transepithelial electrical resistance

Instead, the benefits tend to build up over several weeks as your cellular levels stabilize

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While increased surface area and dense ligand presentation can enhance local drug concentration and enable sustained, controlled release, these same features can intensify chemical interactions with host cells and increase toxicity [148]