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Although measuring adaptive behavior was not a primary outcome of that trial, the improvements in this assessment gained the FDA's breakthrough therapy label (56)

In a model mouse with autism-like behavior induced by prenatal exposure to a cafeteria diet, ADF increased anti-inflammatory CD206 + microglia in the hippocampus, reduced ER stress markers (BiP, ATF6, p-JNK), and improved social interaction

As the dose increased, six cases of hypoglycemia occurred in five participants, between 30 and 60 min after IN-105 was administered

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