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Prospective BASECAMP-1 experience in patients with gastrointestinal (GI) cancer: Identifying patients with human leukocyte antigen (HLA) loss of heterozygosity (LOH) for a future therapeutic trial exploiting LOH as a tumor vulnerability
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The complementary mechanisms underlie this efficacy: HBO directly ameliorates tissue hypoxia by elevating oxygen partial pressure, while mild hypothermia (typically maintained at 33-35C) reduces cerebral metabolic rate, attenuates excitotoxicity, and suppresses inflammatory cascades[100]
High-grade Prostatic Intraepithelial Neoplasia of the Prostate: The Precursor Lesion of Prostate Cancer
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