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Table 1 Trained immunity in inflammatory diseases: from metabolic dysregulation to epigenetic reprogramming

In addition, Bacteroidetes also produce bile salt hydrolase (BSH), which hydrolyzes conjugated BAs and regulates BAs-mediated lipid metabolism (Tian et al., 2019)

However, when produced in excess, they can lead to oxidative damage over time, disrupting cellular functions and ultimately causing cell death by harming DNA, RNA, lipids, and proteins (Isik et al

According to the analysis of specific cell growth and the rate of -PL production, a novel two-stage pH control method was developed by changing the culture pH from 3.5 to 3.8 after 36 h, which increased the -PL yield and productivity from 7.8 g/L and 3.1 g/L/day to 9.1 g/L and 4.8 g/L/day, respectively [81]