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The short answer is that for many people with hypothyroidism, these treatments can be used, but they require a very specific, careful, and doctor-led approach

doi:10.1016/j.jns.2009.04.003 37

for example, isoniazid, cycloserine, penicillamine, and hydralazine each form complexes with B or otherwise interfere with B metabolism, potentially leading to deficiency and peripheral neuropathy