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This process involves the inhibition of signaling pathways and the alteration of histones, resulting in the reduction of inflammatory macrophages that drive M2-like polarization towards a reparative phenotype (128, 129)

Glutathione is the most abundant antioxidant in our cells, playing a central role in antioxidant defenses, and is synthesized from three amino acids glutamate, cysteine, and glycine

FIGURE 3 Abnormal Cell Cycle Progression in Oocytes and Zygotes of Affected Patients Gene Ontology analysis revealed that the differentially expressed transcripts in GV oocytes and 1-cell embryos were consistently enriched in chromosome segregation and DNA repair process as the top 10 enriched biological processes (BPs) (Figure 3D)