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115 116 Mechanistically, alcohol-induced CYP2E1 overexpression enhances HBV replication by upregulating hepatocyte nuclear factor-4, the key transcription factor for the HBV core promoter, 117 and increases HCV-related mitochondrial ROS, reducing antioxidant capacity and depleting mitochondrial glutathione, which heightens oxidative damage and cell death

In these reactions, GSH is converted to intermediate products like glutathiyl radicals and sulfenic acids

doi: 10.1016/j.biopha.2016.04.022 67 TortorellaSMRoyceSGLicciardiPVKaragiannisTC

Interact Cardiovasc Thorac Surg 31(2):282, 2020

On the other hand, closed comedones, commonly referred to as whiteheads, are primarily a result of excess sebum production and the accumulation of dead skin cells that block hair follicles