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A more recent analysis of real-life data from a very large US claims database, including almost 150,000 patients with T2DM and NPDR found no protective effect of statin use on the risk of progression to VTDR, PDR, DME, vitreous hemorrhage or retinal detachment [54]

This form of EDTA for use as chelation therapy in lead poisoning was approved by the US Food and Drug Administration (FDA) in 1950 (Flora and Pachauri, 2010)