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Though participation in RT has increased in females in recent years (Kraemer et al., 2025), many older females still report hesitancy, citing a lack of education and beliefs that any heavy lifting should be avoided (Hurst et al., 2023)

Notably, Fasn and Scd1 are target genes of SREBP1 25 , and Cpt-1 and Acox1 are PPAR/PGC-1 regulated genes 26

These observations collectively offer a novel opportunity to treat porphyria by targeting the Wnt/beta-catenin signaling pathway

For oral supplements, most experts suggest doses between 250 to 500 mg daily