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Primary outcome measures included safety (determined by maintenance of corneal transparency and absence of rejection, scarring, inflammation or neovascularization detected during clinical examinations up to 6 months post-operatively) and efficacy measures to assess reduction in maximum keratometric power, increase in corneal thickness and improvement in uncorrected and BCVA at 6 months

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coli 15,017, providing effective auxiliary validation for evaluating combination therapy efficacy

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MIC stands for L-Methionine, Inositol and Choline