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With advancing age, the accumulation of toxins and the increasing damage from oxidative stress contribute to the development of a wide range of diseases and accelerate the ageing process

Ekerot M, Stavridis MP, Delavaine L, Mitchell MP, Staples C, Owens DM, et al

An increase in tyrosine hydroxylase and dopamine transporter immunoreactivity in SNpc of PD mice was also observed after MP treatment

Nat Rev Microbiol 22 , 155169 (2024)

Metabolic studies using radiolabeled curcumin in rats, when administered at 400 mg/animal, about 40% of the unaltered form of curcumin was found in the feces (Ravindranath and Chandrasekhara, 1981b)