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Emerging epidemiological evidence suggests notable shifts in both microbiota composition and metabolism in CRC patients, underscoring the complex interactions between gut microbes and the disease [3, 4]

According to Fitzgerald et al., fumarate, an intermediate in the tricarboxylic acid cycle, succinylates cysteine in GSDMD, inhibits its interaction with and activation of cysteine proteases, and ultimately inhibits the occurrence of pyroptosis

Following the initial report, the responsible person must submit follow-up reports of new medical information that they receive for one-year

Based on results from recent studies, this may be explained based on the premise that in some cell types, the activity of NO is influenced by the endogenous antioxidant, GSH [10]

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