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Although individuals with SCD often maintain independence, many experiences daily challenges such as medication adherence, financial management, and household tasks (Tuokko and Smart, 2018)

S -nitrosoglutathione (GSNO) as a biological NO donor has a very important function in NO signaling since it can transfer its NO moiety to other proteins ( trans -nitrosylation)

The ER integrates nutrient sensing across cell types through regulation of calcium fluxes and lipid metabolic programs, coordinating cellular responses to metabolic fluctuations (113)