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Carthamin yellow mitigated the effects of MCAO-induced ferroptosis by reducing iron and ROS accumulation, decreasing LPO, and restoring the expression levels of proteins linked to ferroptosis ( 2+ and ROS and restored the levels of ACSL4, TFR1, GPX4, and FTH1 proteins in the brain ( 5.3 Polyphenols Polyphenols are formed by direct connection between hydroxyl (-OH) groups and aromatic nuclei (benzene rings or condensed benzene rings)

In Table 1 , the key targets in the pathophysiology of glycolysis-related OA and their subtypes are summarized

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These mechanisms include the activation of the zinc finger transcription factor CREB-mediated IL-6/STAT3/cyclin D1 pathway, the overexpression of neuropilin-1 (NRP-1), vascular endothelial growth factor (VEGF), and matrix metalloproteases (MMP-2 and MMP-9), repression of zona occludens-1 (ZO-1) and claudin-1 by zinc finger E-box binding homeobox 1 (ZEB1), and RAB27B-mediated release of extracellular vesicles from cancer cells 8183 ( Figure 3C )