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They contain functional mitochondria and other intracellular organelles

To this end, modulating neuronal plasticity in the ACC holds immense promise for alleviating neuropathic pain, and further investigation is therefore needed to explore novel therapeutic agents, such as PKM inhibitors (Li et al., 2010), in alleviating ACC hyperexcitability and CIPN symptoms

Hydrogen peroxide (H 2 O 2 ), a naturally occurring reactive oxygen species (ROS), is seen as a harmful molecule involved in the onset of these diseases

Finally, the sections were dehydrated, cleared, and mounted

These studies implied TMAO-mediated aggregation of unfolded or misfolded proteins may be another mechanism linking TMAO to UPR