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Oral supplementation of vitamin C notably alleviates symptoms like gingival bleeding and swelling, promoting the overall health of periodontal tissues ( Studies show that vitamin C usefully alleviates clinical symptoms and the risk of disease progression in periodontitis through alleviating oxidative pressure and inflammatory mediator release ( Besides, local application of vitamin C in the oral environment has also been studied for its antioxidant and anti-inflammatory properties in alleviating the severity of gingival inflammation ( 4.1.2 Effects of vitamin E application Vitamin E, as a fat-soluble antioxidant, displays vital advantages following oral supplementation, in particular in the protection and improvement of periodontal tissues ( Moreover, vitamin E contributes to promote the condition of periodontal pockets and lessen gum discomfort and inflammation in patients ( 4.1.3 Clinical application of glutathione As the major intracellular antioxidant, glutathione effciently alleviates oxidative pressure levels in periodontal tissues ( Clinical trials show that glutathione supplementation apparently promotes oral health indicators in patients, like lessening periodontal pocket depth and gingival bleeding index

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