B12 is fundamental to a number of important metabolic processes, including: Red blood cell formation Nervous system function Nutrient absorption Adrenal gland support Cognitive function and memory Brain cell regeneration DNA synthesis Mitochondrial metabolism Male and female reproductive health Because of its important role in the nervous system, severe B12 depletion over time can lead to irreversible neurological damage

Acknowledgments The authors thank Trudy Mcgarry, PhD (Novartis, Dublin, Ireland) and Shilpa Kakkar, PhD (Novartis Healthcare, Hyderabad, India) for providing medical writing support which was funded by Novartis Pharma AG in accordance with the Good Publication Practice (GPP3) guidelines ( The authors would also like to thank the patient advocacy groups that participated in this study: APIAFCO (Associazione Psoriasici Italiani Amici della Fondazione Corazza), Canadian Association of Psoriasis Patients, France Psoriasis, GIPSO (Groupe dAide lInformation et la Recherche sur le Psoriasis), Interregional Charitable Public Organization Skin and Allergic Diseases, Irish Skin Foundation, Japan Psoriasis Association, National Psoriasis Foundation, Psoriasis Association Korea, Psoriasis Association of Slovenia, Psoriasis Australia, Psoriasis-Contact, Psoriasis Liga Vlaanderen, Psoriasis og Eksemforbundet, Psoriasisforeningen, and Psoriasis Association Taiwan
Gong, A
Pradhan et al., 2019)
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