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15 Thus, a competition for selenium incorporation would be responsible for the decrease of the biosynthesis or activity of GPxs 1 and 3 leading to accumulation of H 2 O 2 that has been suggested to exert neurotoxic effects promoting oxidative stress and inflammation, which are critical factors of brain damage induced by cerebral ischemia

[DOI] [PMC free article] [PubMed] [Google Scholar] 76.Maret W., Larsen K.S., Vallee B.L

The computational power of supercomputers has increased approximately one millionfold since the 1990s

1,12 [corrected] Clinical evaluation seems to show an inverse relationship between the severity of megaloblastic anemia and the degree of neurologic impairment

However, these mainstream therapies face critical limitations including the rapid emergence of drug resistance, FKS1/FKS2 gene mutations reducing -1,3-glucan synthase affinity, Targeted enzyme (Erg11p) modification, overexpression of efflux pumps (CDR1, MDR1), and upregulation of the ergosterol pathway mediate azole resistance (Pristov and Ghannoum, 2019)