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Author Contributions ED, JDCM, SMLF, ICP and MSB were responsible for conducting the search, screening potentially eligible studies, extracting and analyzing data, interpreting results

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Prx2, initially called calpromotin, is also required to regulate the calcium-dependent potassium channel in the erythrocyte membrane [81]

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While CD34 high and THY1 high ECs are primarily associated with endothelial proliferation and vascular development, activated ECs are enriched in pathways related to vessel dilation and blood pressure regulation [105]