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Furthermore, CPY450-mediated lipid peroxidation serves as a substitute for ALOX in ferroptosis, facilitating polyunsaturated fatty acid (PUFA) peroxidation and causing cancerous cell death

The first step includes the priming of the NLRP3 inflammasomes via the activation of Toll-like receptors such as the Toll-like receptor 4 (TLR4) leading to NF-kB-dependent expression of NLRP3, pro-IL-1 and pro-IL-18