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In parallel, iron dyshomeostasisexpansion of the labile iron pool and damage to FeS clusterslowers the threshold for ferroptosis-like lipid peroxidation in PUFA-rich neuronal membranes, particularly in regions with heavy metabolic demand (Liu et al

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The impressive combination of potent antiviral activity, high target tissue distribution, and clinical efficacy demonstrated from once-daily oral dosing, makes EDP-514 the ideal candidate for continued development in a combination regimen

(download DOCX Effects of inducible nitric oxide synthase (iNOS) inhibition by aminoguanidine (60 mg/kg i.p.) on Trichobilharzia regenti infection in mice 7 days post-infection

At the molecular level, the PINK1/Parkin-dependent pathway for mitochondrial autophagy is a key mechanism [112]