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This Research Topic aims to highlight recent advancements and challenges in MS-based adductomics within biological matrices, and further adductomic approaches to the study of the exposome in health and disease

We also evaluated in vivo biosafety and found no significant weight changes in any of the treatment groups during the experiment (Additional file 1: Fig

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Additionally, tyrosines play an important role in aSyn-vesicle binding while nitration impairs this interaction (making the charge more negative at the N-terminal domain, or causing a conformational change when the C-terminal domain is nitrated) thereby increasing the amount of aSyn in a random coil or beta-sheet conformation and thus shifting equilibrium toward oligomer formation 105,106,109