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The heat generated is confined to the region containing the nanoparticles, minimizing effects on surrounding tissues

That route bypasses the GI tract entirely

21, 2022, Simoes JP, Daoud E, Shabbir M, et al

But the temperature and pressure can be lowered by using a chemical named as carrier

The results showed that ultrasonic treatment significantly accelerated the release rates of both drugs, while multilevel encapsulation enabled sustained release of NGF over one month[356]