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doi: 10.1111/J.1365-2222.2011.03830.X 275 MalekiSJChungSYChampagneETRaufmanJP

The molecular mechanism depicted was via activation of Mitogen-activated protein kinase p38 (p38 MAPK) and the E3 ubiquitin ligase Atrogin1/MAFbx, the latter being up-regulated during immobilization also in humans and involved in increased proteasome activity [129]