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The engagement of the glutathione system in astroglial cells contributes to the reduction in its antioxidant defenses and so poor glial defense could contribute to existing neuronal damage (Figure 5) [10]

It further explores recent progress in therapeutic approaches, including natural bioactive compounds, small molecules and nanotechnology-driven combinations

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During the preparation of this work, the authors used ChatGPT (OpenAI) for language editing, figure organization, and clarity improvement, and Consensus for literature search support

Not too much has been happening this past year, says Vincent DAloia