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In most cases, symptoms should improve within 2-4 weeks as tolerance develops

While these effects are beneficial in specific contexts such as treating growth hormone deficiency in children, muscle wasting conditions, or severe catabolism, they create unwanted consequences when the goal is simply fat reduction

Timing of administration relative to surgical procedures, optimal dosing in perioperative settings, and integration with standard post-operative care protocols require clinical investigation before establishing evidence-based perioperative protocols

These findings have contributed to growing scientific interest in NNMT as a target for metabolic research