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Low levels can cause: Tingling or numbness in hands and feet Difficulty walking or balance problems Muscle weakness Memory problems Poor concentration Mood changes (depression, irritability) Cognitive decline in severe cases Other B12 deficiency signs Sore or red tongue Mouth ulcers Vision disturbances Dizziness Cold hands and feet Causes of Vitamin B12 Deficiency Vitamin B12 deficiency happens either due to low intake or poor absorption

Whilst mTORC1 activates S6 kinase, which phosphorylates serine residues on IRS which in turn uncouples IRS from the receptor and its substrates, mTORC2 can reactivate this signalling

Extracellular acid block and acid-enhanced inactivation of the Ca 2+ activated cation channel TRPM5 involve residues in the S3-S4 and S5-S6 extracellular domains

This targeted approach complements the regenerative functions of MSCs and exosomes mentioned earlier