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Acknowledgement ABCD Europe gratefully acknowledges the support of Boehringer Ingelheim (the founding sponsor of the ABCD), MSD Animal Health, Vtoquinol and Virbac

SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase

Nat Commun 12:1589

10.1038/s41388-018-0243-y 17 BogaczM.Krauth-SiegelR

These results demonstrate that inhibiting ferroptosis, rather than activating the AMPK pathway, is the primary mechanism of action of metformin against IIRI