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FMT holds promise as a therapeutic intervention by modulating the gut microbiota and stimulating the synthesis of neurotransmitters or their precursors, such as serotonin, dopamine, and GABA, thus potentially ameliorating symptoms associated with depression

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showed that proteosome inhibitors bortezomib, carfilzomib, oprozomib (ONX 0912), and immunoproteasome inhibitor ONX 0914 (previously PR-957) reduced B-cell proliferation, immunoglobulin production, and induced apoptosis of activated B-cells (96)

Additional factors, such as reduced Lactobacilli abundance, increased production of mucosal injury mediators and recurrent mixed microbial infections, all play a role in compromising epithelial barrier integrity