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12 Beclin-1-mediated autophagy regulation and apoptosis In apoptosis, proteins like caspases 3, 6, and 7 destroy cells by cutting numerous proteins (279, 280)

In aging and dedifferentiated chondrocytes, researchers found that IGF-1 expression level was downregulated

PMC 9066945

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Another explanation for the inconclusiveness of human studies is that these studies largely examine the link between the adult body burden of EDCs and the incidence of disease without regard to the timing of the initial exposure