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A 2006 study published in the British Journal of Dermatology found that afamelanotide increased eumelanin production by 3.5-fold in Type I skin after 14 days of dosing, compared to 1.8-fold in Type III skin, because the baseline melanocyte density and receptor expression differ significantly between phenotypes

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Consistent use of an appropriate amount will yield the best results over time

This also helps people get better control of their blood sugar, or glycemic control