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Epigenetic modifications have been reported to induce a series of changes in gene expression and protein levels that result in mitochondrial abnormalities and neuronal apoptosis and lead to PD (Zhang et al., 2021), long non-coding RNAs ( Mitochondrial Quality Control in Parkinsons Disease Quality control mechanisms are essential to maintaining a healthy mitochondrial network and cell homeostasis, especially to dopaminergic neurons

Reaction 3: 6-Phosphogluconate + NADP Ribulose-5-Phosphate + CO + NADPH + H The second reaction involves the oxidation of 6-phosphogluconate, which results in the production of NADPH, carbon dioxide (CO), and ribulose-5-phosphate

Therefore, the suggested mechanistic model may consist of two consecutive phases: (i) the transferring of selenium between selenol (R-Se-H) and selenenic acid (R-SeO-H) followed by (ii) the transferring of selenenic acid (R-SeO-H) to seleninic acid (R-SeOO-H) although this has not been experimentally verified

S.Ferrer-SuetaG.et al (2020)