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Smokers melanosis . Oral pigmentation seen in heavy smokers . Investigations have shown ability of melanin to bind to noxious substances. . Exposure to polycyclic amines ( Nicotine & benzpyrene) has shown Pigmented lesions of the oral cavity: An Update PMC Oral pathology: Noting a pigmented macule that often presents a diagnostic dilemma Registered Dental Hygienists Diagnosis of oral pigmentations and malignant transformations ScienceDirect Oral pigmented lesions: Clinicopathologic features and review of the literature PMC
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