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As noted above, SOD1/2 (Cu/Zn and Mn, respectively), CAT, and GPx catalyze the dismutation of O to O 2 and H 2 O 2 and the subsequent decomposition of the latter to O 2 and H 2 O

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Inhibiting PFKFB3 activity in an in vitro IR model blocks glycolytic activation, forcing neurons to switch to the PPP metabolic pathway, thereby realizing a neuroprotective effect (54)