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Narcan removes opioids from receptors in the central nervous system and replaces the opioids without activating the receptor

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Over the years, disulfide-containing compounds (-SS-) have been extensively explored in the development of GSH-sensitive drug delivery systems (DDSs) [52]

Considering the volume of the mitochondrial matrix, the concentration of mitochondrial GSH (mGSH) is similar to that of cytosol (1014 m M ) (44, 48, 95)

As a biomarker in clinical practice, it has been suggested as a proxy to evaluate neuroinflammation ( Although CNS IDDs might differ in several aspects, as previously mentioned, the extensive role performed by glial cells in neuroinflammation is a convergence point among them