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Considering the good response to the first multimodal treatment, we decided to schedule a second cycle of oral and topical treatment for 12 months, using the same agents and doses and reducing the frequency of peri-plaque penile injections with pentoxifylline 100 mg to one penile injection every 2 months for 12 months

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However, the addition of trisomy 21 in the first case, and raised adenosine in the second, brings the profiles much closer to those observed in patients with Down syndrome and autism, respectively

However, macrophages deficient in different NOX isoforms (such as NOX1, NOX2 and NOX4) respond normally

Some studies have also indicated potential roles in cartilage regeneration and immune-related pathways