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Two key regulatory pathways (p16-CDK4-RB and ARF-MDM2-p53 pathway) are involved in controlling cells duplication activities from unrestrained progression of cell cycles, whereby the principal proteins involved in these distinct pathways are retinoblastoma tumor suppressor protein (RB) and p53 tumor suppressor protein (Fig

Underlying mechanisms are incompletely defined but include intraoperative and postoperative phenomena, such as inflammation, sympathetic activation and cardiac ischaemia, that combine to trigger atrial fibrillation, often in the presence of pre-existing factors, making the atria vulnerable to atrial fibrillation induction and maintenance

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In 2003, Joe admitted to whipping them as children, but he emphatically rejected the longstanding abuse allegations

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