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At this stage, VSMCs not only lose contractile phenotype but also acquire macrophage-like and inflammatory characteristics, secreting factors such as IL-1 and MMPs that exacerbate plaque instability

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The team also participates in peer discussions and collaborates with specialists across disciplines to integrate cutting-edge therapies that improve patient outcomes

Environmental exposures, such as heavy metals, further impair the composition of the gut microbiota, which amplifies oxidative damage [238, 239]

Meixiao Zhan, Email: [email protected]