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These restrictions and warnings demonstrate the FDAs stringent consideration of patient safety in the drug approval process

The activation of protein kinase C isoforms and (PKC/), along with the upregulation of NADPH oxidase, further enhances ROS production ( Due to its hydrophobic nature, 4-HNE readily integrates into the mitochondrial phospholipid bilayer, disrupting lipid organization and increasing membrane permeability (Santin et al., 2020)

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A reduction in cerebral blood flow can lead to metabolic dysfunction and secondary brain injury

Chronic inflammation has been associated with the development of malignancy in several other organs such as the oesophagus, stomach, colon, liver and urinary bladder