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The honest framing has three parts: This is mechanistic reasoning, not a demonstrated effect

Increased indirect neurogenesis might contribute to the anterior CNS expansion evident throughout the Bilateria and help to modify brain-region size without requiring increased NPC numbers or extended neurogenesis

Eleni Gentekaki for her constructive comments and critique on the manuscript

Acknowledgements The authors thank Line Zurkinden, Edgar Ontsouka and Michael Lthi at the Institute of Biochemistry and Molecular Medicine, University of Bern for their helpful support in conducting the RT-qPCR analyses