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Splicing factor SF3B1K700E mutant dysregulates erythroid differentiation via aberrant alternative splicing of transcription factor TAL1

Research and investigation evidence indicates that diet is considered a potential environmental factor in the development or progression of PD, and there is growing evidence that diet may play an important role in PD (8)

As a negative feedback mechanism, excessive lipid peroxidation can inhibit STING1 activation through lipid-aldehyde 4-hydroxynonenal/4-HNE binding to STING1, resulting in STING1 carbonylation at Cys88 [185]

Furthermore, the patients response to methylprednisolone treatment and the findings of scattered unidentified bright objects (UBOs) on brain MRI are more suggestive of a demyelinating process than a nutritional deficiency

doi: 10.3389/fragi.2025.1603916 Received 01 April 2025 Accepted 05 May 2025 Published 21 May 2025 Volume 6 - 2025 Edited by Augusto Schneider, Federal University of Pelotas, Brazil Reviewed by Driele Garcia, Federal University of Pelotas, Brazil Jessica Hense, Federal University of Pelotas, Brazil Updates Copyright 2025 Xie, Chen, Xu, Miao, Zheng, Jiang and Sun