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Prolonged hepatotoxicity with associated regenerative hyperplasia can be associated with and lead to liver tumor development (Evans and Lake 1998

Subsequent NF-B pathway activation drives macrophage recruitment and amplifies inflammatory cytokine production (374)

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Age and degree of GH axis decline: Patients in their late 40s and 50s typically see more dramatic early results than patients in their mid-30s starting preventively, because GH decline is more advanced and the pituitary still has enough reserve capacity to respond meaningfully to stimulation