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These findings suggest that defects in the remethylation and transsulfuration pathways may contribute to the elevated homocysteine levels observed in children with autism spectrum disorder.35 Epidemiological studies have found that individuals experiencing major depressive disorder and bipolar disorder have elevated plasma levels of homocysteine and deficient plasma levels of folate and vitamin B12.35 The effect of reducing plasma homocysteine levels on the symptomology of these neurological disorders has not been well-studied, and clinical trials investigating associations between folic acid and vitamin B12 supplementation and mood disorders have provided inconsistent results

Circadian periodicity of blood amino-acids in adult men

If you dont have enough B12, you can end up developing a certain kind of anemia known as megaloblastic anemia

Instead, the first event reflects only reduction of the flavin, NADPH oxidation, and the accumulation of a small charge transfer absorption with absorbance centering around 650 nm