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There is large evidence that HGF can mediate neuroinflammation in the context of neurodegenerative autoimmune diseases such as multiple sclerosis (MS), leading to an indirect effect on the immune system

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The T-cell receptor (TCR) is a specific receptor present on the surface of T cells that initiates first transduction signals by specifically recognizing and binding antigenic peptides presented by the major histocompatibility complex (MHC) on the surface of APCs, thereby inducing T-cell activation and performing adaptive immune functions [84]

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Role of NLRP3 inflammasome/caspase 1 signaling pathway in cyclophosphamide-induced ovarian injury Inflammasomes, which are multiprotein complexes, assemble in the cytoplasm and are triggered by many endogenous and exogenous stimuli, including ROS and DAMPs