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In addition, molecules secreted by senescent cells up-regulate inflammation, cause direct cellular damage, disrupt repair mechanisms involving stem cells, and even induce senescence in other cells, leading to widespread pulmonary dysfunction (Kirkland 2017)

It is worth noting that Fig.3 highlights four major issues affecting the effectiveness and safety of Se-based treatments: (1) a narrow therapeutic window requiring precise dosing to avoid toxicity or ineffectiveness

coli mutants could provide further insights into how gut microbiota influences host longevity

The microbiota as a modulator of mucosal inflammation and HIV/HPV pathogenesis: From association to causation