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The H&E staining images of heart, liver, spleen, lung, kidney and stomach tissues of mice gave additional evidences to demonstrate the excellent in vivo biosafety of ATRA-ATO-NPs: no obvious histological abnormalities or damages were detected in the heart, liver, spleen, lung, kidney and stomach of mice after ATRA-ATO-NPs treatment even at high concentrations of 150 and 600 mg kg 1 (Fig

while the latter is usually considered safe, the body will absorb only a small percentage of that amount

In general, BRVO has a good prognosis: 5060% of eyes are reported to have a final visual acuity (VA) of 20/40 or better even without treatment