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Okeleji O, Singh S, Bedoy A, Ostermann L, Garland KM, Mak PY, Pacheco C, Ayoub E, Veletic I, Angel M, Luther S, Rohde C, Andreeff M

Glutathione metabolism and its implications for health, Pubmed

11 , 86875.e753 (2013)

However, other pathophysiological modifications within melanoma cells may contribute to therapy resistance [4, 5], demanding for large-scale computational models to simulate the complex physiology of a tumour in an integrated manner and comprehensively foster the identification of alternative therapeutic vulnerabilities applying high throughput in silico approaches [6, 7]

The XKR8 germline KO, floxed and 2DA mutant KI mice were generated for this study