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Liver-specific PHGDH knockout (KO) mice fed a chow diet show higher adiposity and reduced glucose tolerance (25)

The sample was collected from the fine sediment (top 1020 cm), stored in sterile 50 mL Corning Falcon tubes (Sigma-Aldrich, Gillingham, United Kingdom), and shipped in cooling boxes at 4 C to the Open University (UK) within 7 days of sampling

The amounts of metabolized glucose (M) and plasma insulin concentration (I) were determined

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In adulthood, it is expressed mainly in the liver and non-genital skin and is expressed in very low levels in the prostate, genital skin, and internal duct structures (1)