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Unfortunately, your body's ability to produce glutathione naturally decreases with age, typically starting around age 20 and declining by approximately 1% per year

demonstrated that Nutlin-3, a murine double min 2 (MDM2) small molecule inhibitor, could function as a novel DNMT inhibitor via enhancing p53 and RB expression, making it a promising DNMT inhibitor for sensitizing chemoradiation-resistant ESCC to therapy [143]